Proteolytic Processing of Alzheimer's Disease βA4 Amyloid Precursor Protein in Human Platelets
نویسندگان
چکیده
منابع مشابه
amyloid precursor protein processing in alzheimer’s disease
how to cite this article: bhadbhade a, cheng dw. amyloid precursor protein processing in alzheimer’s disease. iranian journal of child neurology2012;6(1):1-5. alzheimer’s disease (ad) is a progressive neurodegenerative disorder and a leading cause of dementia. the ad is characterized by presence of intraneuronal tangles and extracellular plaques in the brain. the plaques are composed of dense a...
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The proteolytic processing of the amyloidprotein precursor plays a key role in the development of Alzheimer’s disease. Cleavage of the amyloidprotein precursor may occur via two pathways, both of which involve the action of proteases called secretases. One pathway, involving and -secretase, liberates amyloidprotein, a protein associated with the neurodegeneration seen in Alzheimer’s disease. Th...
متن کاملAmyloid Precursor Protein and Amyloid b Peptide in Human Platelets
The main component of Alzheimer’s disease (AD) senile plaques is amyloid-b peptide (Ab), a proteolytic fragment of the amyloid precursor protein (APP). Platelets contain both APP and Ab and may contribute to the perivascular amyloid deposition seen in AD. However, no data are available concerning the biochemical mechanism(s) involved in their formation and release by these cells. We found that ...
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Objective(s): Increasing evidence suggests that Alzheimer’s disease (AD) is associated with diabetes. Rosiglitazone, a peroxisome proliferator-activated receptor γ (PPAR-γ) agonist and anti-diabetic agent, may improve symptoms of AD. However, the underlying therapeutic potential of it has not been fully elucidated. Materials and Methods: Rats were divided into four groups: control group, sham o...
متن کاملAmyloid precursor protein processing and Alzheimer's disease.
Alzheimer's disease (AD), the leading cause of dementia worldwide, is characterized by the accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated and cleaved forms of the microtubule-associated protein tau. Genetic, biochemical, and behavioral research suggest that physiologic generation of the neurotoxic Aβ peptide from sequential amyloid precursor protein (...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1995
ISSN: 0021-9258
DOI: 10.1074/jbc.270.23.14140